Product Description

ARHGAP17 (T363) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3390-50, BS3390-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resμlting in down regμlation of their active form. ARHGAP17 (Rho GTPase activating protein 17), also known as RICH1, WBP15, MST066, MST110, NADRIN, PP4534, RICH1B, MSTP038, MSTP066 or MSTP110, is a ubiquitously expressed peripheral membrane protein whose expression is highest in heart and placenta. ARHGAP17 is involved in the maintenance of tight junctions by regμlating the activity of Cdc42, thereby playing a central role in apical polarity of epithelial cells. Containina a BAR domain and a Rho-GAP domain, ARHGAP17 acts as a GTPase activator for the Cdc42 GTPase by converting it to an inactive GDP-bound state. ARHGAP17 may also participate in the Ca2+-dependent regμlation of exocytosis by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of cortical actin filaments. ARHGAP17 exists as seven alternative splice variants.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Zinc finger CCCH domain-containing protein 7B, Rotavirus 'X'-associated non-structural protein, RoXaN, ZC3H7B, KIAA1031

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 845-905 of Human RoXaN.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ARHGAP17(T363) Polyclonal Antibody detects endogenous levels of ARHGAP17 protein.

Molecular Weight: ~ 130 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q68EM7

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only