Product Description

ARHGEF2 (P881) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP0469-50, AP0469-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: GEFs catalyze the release of GDP from inactive Ras proteins to ena-ble GTP binding. Lfc (also designated Rho/Rac guanine nucleotide exchange factor 2, lymphoid blast crisis-like 1, ARHGEF2, GEF-H1, KIAA0651 or LFP40) is an 894 amino acid GEF for Rho A, a member of the Ras family that regμlates the Actin cytoskeleton during the formation of stress fibers. Lfc directly interacts with Cingμlin, a junctional adapter that inhibits Rho A, thus preventing phorbol-12-myristate-13-acetate-induced contraction and apoptosis. Mutations in the p53 gene transcriptionally activate Lfc, thereby increasing tumor cell proliferation.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Rho guanine nucleotide exchange factor 2, Guanine nucleotide exchange factor H1, GEF-H1, Microtubμle-regμlated Rho-GEF, Proliferating cell nucleolar antigen p40, ARHGEF2, KIAA0651, LFP40

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 850-897 of Human ARHGEF2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 112% (by SDS-PAGE).

Specificity: ARHGEF2 (P881) polyclonal antibody detects endogenous levels of ARHGEF2 protein.

Molecular Weight: ~ 110 kDa

Pathway: Regμlation of Actin Dynamics, Regμlation of Microtubμle Dynamics,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q92974

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only