Arkadia Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA22074-50, RA22074-100
Citations, Manuals and MSDS Available upon request.
Background: ring finger protein 111 (RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Alternative Names: RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse
GeneID (Human): 54778
Protein MW (KDa): 110
SWISS: Q6ZNA4
Source: Rabbit
Research Use Only