Arkadia rabbit pAb - ES6675

Arkadia rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6675-50, ES6675-100

Citations, Manuals and MSDS Available upon request.

Background: ring finger protein 111 (RNF111) Homo sapiens The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012],

Alternate Name: RNF111; E3 ubiquitin-protein ligase Arkadia; RING finger protein 111

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human RNF111. AA range:901-950

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 110kD

Human Gene ID: 54778

Human SWISS Prot NO: Q6ZNA4

Subcellular Location: Nucleus. Cytoplasm. Nucleus, PML body. Upon TGF-beta treatment, translocates from nucleus to cytosol.

Research Use Only