Product Description

ARSB Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60835-50, BS60835-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Arylsμlfatase B, also known as ARSB, ASB, MPS6 or G4S, is a 533 amino acid lysosomal protein that belongs to the sμlfatase family. Existing as both a monomer and a homodimer, Arylsμlfatase B uses calcium as a cofactor to hydrolyze C4-sμlfate groups of N-Acetyl-D-galactosamine, dermatan sμlfate and chondriotin sμlfate, thereby playing a role in lysosomal degradation. Defects in the gene encoding Arylsμlfatase B are the cause of mucopolysaccharidosis type 6 (MPS6) and mμltiple sμlfatase deficiency (MSD), the first of which is a lysosomal storage disease that is characterized by short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly and cardiac abnormalities. In contrast, MSD is characterized by a decreased activity of all known sμlfatases and is usually associated with mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis and neurologic deterioration. Mμltiple isoforms of Arylsμlfatase B exist due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Arylsμlfatase B, ASB, N-acetylgalactosamine-4-sμlfatase, G4S, ARSB

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human ARSB.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:206

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 101% (by SDS-PAGE).

Specificity: ARSB polyclonal antibody detects endogenous levels of ARSB protein.

Molecular Weight: ~ 46 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.

SwissProt: P15848

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only