ARSB Polyclonal Antibody
Catalogue Numbers: BS60835-50, BS60835-100
Sizes: 50µl, 100µl
Alternative Name: Arylsulfatase B; ASB; N-acetylgalactosamine-4-sulfatase; G4S; ARSB
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P15848
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
IHC: 1:50~1:206
Background: Arylsulfatase B, also known as ARSB, ASB, MPS6 or G4S, is a 533 amino acid lysosomal protein that belongs to the sulfatase family. Existing as both a monomer and a homodimer, Arylsulfatase B uses calcium as a cofactor to hydrolyze C4-sulfate groups of N-Acetyl-D-galactosamine, dermatan sulfate and chondriotin sulfate, thereby playing a role in lysosomal degradation. Defects in the gene encoding Arylsulfatase B are the cause of mucopolysaccharidosis type 6 (MPS6) and multiple sulfatase deficiency (MSD), the first of which is a lysosomal storage disease that is characterized by short stature, stiff joints, skeletal malformations, corneal clouding, hepatosplenomegaly and cardiac abnormalities. In contrast, MSD is characterized by a decreased activity of all known sulfatases and is usually associated with mucopolysaccharidosis, chondrodysplasia punctata, hydrocephalus, ichthyosis and neurologic deterioration. Multiple isoforms of Arylsulfatase B exist due to alternative splicing events.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 101% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.
Specificity: ARSB polyclonal antibody detects endogenous levels of ARSB protein.
Bioworld Molecular Weight: ~ 46 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of ARSB polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: sp2/0 whole cell lysate
Lane 3: H9C8 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human ARSB.
Conjugate: Unconjugated
Modification: Unmodified