ASC-1 Polyclonal Antibody - BT-AP00663

ASC-1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00663-20, BT-AP00663-50, BT-AP00663-100

Citations, Manuals and MSDS Available upon request.

Background: TRIP4 (thyroid hormone receptor interactor 4) encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in TRIP4 are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1).

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: TRIP4

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: ASC-1 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 66146

UniProt Accession: Human: Q15650; Mouse: Q9QXN3

Synonyms: TRIP4; Activating signal cointegrator 1; ASC-1; Thyroid receptor-interacting protein 4; TR-interacting protein 4; TRIP-4

GeneID: Human: 9325; Mouse: 56404

Research Use Only