ASCC1 rabbit pAb - ES18235

ASCC1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES18235-50, ES18235-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from human ASCC1 AA range: 289-339

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 51008

Human SWISS Prot NO: Q8N9N2

Subcellular Location: Nucleus. Nucleus speckle. Colocalizes with PRPF8 in nuclear speckles in the absence of DNA damage.

Research Use Only