Product Description

ASPH Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-61378-60, E-AB-61378-120, E-AB-61378-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: ASPH

Target Synonym: ASPH; AAH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN; junctin

Research Areas: Cancer, Neuroscience, Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: IF

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q12797

Background: This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human ASPH (NP_001158227.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification Method: Affinity purification

Dilution: IF 1:50-1:100

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only