AT7L3 Polyclonal Antibody - BT-AP14362

AT7L3 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP14362-20, BT-AP14362-50, BT-AP14362-100

Citations, Manuals and MSDS Available upon request.

Background: The SGF11-type zinc finger mediates the interaction with USP22 and ENY2.,Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex.,Belongs to the SGF11 family.,Contains 1 SCA7 domain.,Contains 1 SGF11-type zinc finger.,subunit:Component of some SAGA transcription coactivator-HAT complex, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitinylation. Interacts directly with ENY2 and USP22.,

Research Areas: Cell biology; Epigenetics and nuclear signaling

Target Protein: ATXN7L3

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Ataxin-7-like protein 3

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q14CW9; Mouse: A2AWT3

Synonyms: Ataxin-7-like protein 3;SAGA-associated factor 11 homolog

GeneID: Human: 56970

Research Use Only