ATF6 Polyclonal Antibody - E-AB-70158

ATF6 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-70158-60, E-AB-70158-120, E-AB-70158-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: ATF6

Target Synonym: Activating Transcription Factor 6; CAMP-Dependent Transcription Factor ATF-6 Alpha; Activating Transcription Factor 6 Alpha; Cyclic AMP-Dependent Transcription Factor ATF-6 Alpha; ATF6-Alpha; ACHM7; ATF6A.

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse, Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: P18850,F6VAN0,G3V909

Background: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.

Concentration: 1 mg/mL

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ATF6

Buffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: IHC 1:200-1:1000

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only