ATF6A rabbit pAb - ES18210

ATF6A rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES18210-50, ES18210-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011],

Source: Rabbit

Applications: WB

Dilution: WB 1: 500-2000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human ATF6A AA range: 221-271

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 90kD

Human Gene ID: 22926

Human SWISS Prot NO: P18850

Subcellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Translocates from the endoplasmic reticulum to the Golgi, where it is processed.; [Processed cyclic AMP-dependent transcription factor ATF-6 alpha]: Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus (PubMed:10564271, PubMed:12782636). THBS4 promotes its nuclear shuttling (By similarity).

Research Use Only