ATF7 Polyclonal Antibody-BS90102

ATF7 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90102-50, BS90102-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P17544(Human) Q8R0S1(Mouse) Unigene:219706(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF, IHC, FC

All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.Isoform 5/ATF-4 acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: ATF7 polyclonal antibody detects endogenous levels of ATF7 protein.

Bioworld Molecular Weight: 53 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining ATF7 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining ATF7 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: cAMP-dependent transcription factor ATF-7, ATF7, 1110012F10Rik, 9430065F09Rik, Activating transcription factor 7, AI549878, ATF7, Atf7 protein, ATF7, ATFA, C130020M04Rik, cAMP-dependent transcription factor ATF-7, Cyclic AMP-dependent transcription factor ATF 7, Cyclic AMP-dependent transcription factor ATF-7, MGC31554, MGC57182, Transcription factor ATF A, Transcription factor ATF-A,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified