Product Description

ATG4A Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS62343-50, BS62343-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Autophagy, a process that resμlts in the lysosomal-dependent degradation of cytosolic compartments, is carried out by the autophagosome, which is a double-membrane vesicle whose formation is catalyzed by several autophagy-related gene (Atg) proteins. Atg4a (ATG4 autophagy related 4 homolog A), also known as APG4A or AUTL2, is a 398 amino acid protein that localizes to the cytoplasm and belongs to the peptidase C54 family. Expressed in a variety of tissues, including brain, skeletal muscle and fetal liver, Atg4a functions as a cysteine protease that cleaves the C-terminal part of target proteins, such as GABARAP and MAP1LC3, and plays an essential role in autophagy. Atg4a exists as mμltiple alternatively spliced isoforms and is functionally inhibited by N-ethylmaleimide.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Apg4a, ATG4 autophagy related 4 homolog A (S. cerevisiae), ATG4A, ATG4A_HUMAN, Atg4al, AUT like 2 cysteine endopeptidase, AUT-like 2 cysteine endopeptidase, Autl2, Autophagin 2, Autophagin-2, Autophagy related 4A cysteine peptidase, Autophagy related cysteine endopeptidase 2, Autophagy related protein 4 homolog A, Autophagy-related cysteine endopeptidase 2, Autophagy-related protein 4 homolog A, AV169859, Cysteine protease ATG4A, hAPG4A

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to Human ATG4A.

Dilution: WB:1:500~1:1000 IHC:1:50~1:200 IF:1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: ATG4A polyclonal antibody detects endogenous levels of ATG4A protein.

Molecular Weight: ~ 60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8WYN0

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only