Product Description

ATG4C Monoclonal Antibody

Catalogue Numbers: MB67172-50, MB67172-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: Q811C2

Host: Mouse

Reactivity: Mouse

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: Atg4C (ATG4 autophagy related 4 homolog C), also known as AUTL1 (AUT_x005F_x0002_like 1, cysteine endopeptidase), AUTL3 (AUT-like 3 cysteine endopeptidase),APG4-C, autophagin-3 or cysteine protease ATG4C, is a 458 amino acid tumor suppressor protein belonging to the peptidase C54 family. Encoded by a gene that maps to human chromosome 1p31.3, Atg4C is conserved in chimpanzee,canine, bovine, mouse, rat, chicken and zebrafish. Atg4C is highly expressedin skeletal muscle, heart, liver and testis, and localizes to cytoplasm. Func_x0002_tioning as a cysteine protease, which is necessary for autophagy, Atg4C cleaves the C-terminal region of either MAP1LC3, GABARAPL2 or GABARAP.Atg4C is also inhibited by N-ethylmaleimide.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of ATG4C protein.

Extra Notes: Western blot analysis of ATG4C expression in mouse heart (A) whole cell lysates.

Bioworld Molecular Weight: ~ 52 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: APG4C; AUTL1; AUTL3; Cysteine protease ATG4C; AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C

Immunogen: Recombinant fusion protein of human ATG4C. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified