Product Description

ATIC Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB0029-50, MB0029-100

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P31939

Host: Mouse

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:1000

Background: The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine.

Purification and Purity: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This antibody detects endogenous levels of ATIC and does not cross-react with related proteins

Bioworld Molecular Weight: Predicted band size:64KDa
Observed band size:64KDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western BlotDetection of ATIC in various tissue and cell lysates using ATIC antibody (1:1000 diluted).

Alternative Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase2.IMP cyclohydrolase; ATIC; IMP synthase Inosinicase; PURH; AICAR; AICARFT; IMPCHASE

Immunogen: Recombinant full length Human ATIC.

Conjugate: Unconjugated

Modification: Unmodified