ATM Monoclonal Antibody-MB10331

ATM Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10331-50, MB10331-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q13315

Host: Rabbit

Reactivity: Human

Applications: WB, ICC/IF

All Applications: WB: 1/500-1/1000 IF: 1/50-1/200

Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 351 kDa; Observed MW: 351 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunocytochemistry analysis of ATM in HT-1080 using ATM antibody, and DAPI., Western blot analysis of ATM in Hela, 293 lysates using ATM antibody.

Alternative Name: ATM; Serine-protein kinase ATM; Ataxia telangiectasia mutated; A-T mutated

Immunogen: A synthetic peptide of human ATM

Conjugate: Unconjugated

Modification: Unmodified