ATP-citrate synthase (phospho Ser455) Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA22242-50, RA22242-100
Citations, Manuals and MSDS Available upon request.
Background: ATP citrate lyase (ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Alternative Names: ACLY; ATP-citrate synthase; ATP-citrate; pro-S-) -lyase; ACL; Citrate cleavage enzyme
Applications: WB; IHC-p; IF (paraffin section) ; ELISA
Species Cross-Reactivity: Human; Mouse; Rat; Monkey
GeneID (Human): 47
Protein MW (KDa): 125
SWISS: P53396
Source: Rabbit
Research Use Only