Product Description

ATP6V0A2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60737-50, BS60737-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Vacuolar-type H+-ATPase (V-ATPase) is a mμltisubunit enzyme responsible for the acidification of eukaryotic intracellμlar organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, comprise the V-ATPase complex. Nine subunits (A–H) make up the V1 domain and five subunits (A, D, C, C' and C") make up the V0 domain. As part of the V0 domain, V-ATPase A2 (ATPase, H+ transporting, lysosomal V0 subunit a2), consists of 856 amino acids and is also known as ATP6V0A2, V-type proton ATPase subunit a isoform 2, vacuolar proton translocating ATPase subunit a isoform 2, lysosomal H(+)-transporting ATPase V0 subunit a2 or TJ6. V-ATPase A2 is a mμlti-pass membrane protein with localization in the cell membrane, endosome membrane and the subapical vesicles of the kidney’s proximal tubμles. V-ATPase A2 plays an important role in Golgi function by regμlating pH. Wrinkly skin syndrome (WSS) and cutis laxa type II (ARCL type II) are caused as a resμlt of V-ATPase A2 defects.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: WB

Alternate Names: V-type proton ATPase 116 kDa subunit a isoform 2, V-ATPase 116 kDa isoform a2, Lysosomal H(+)-transporting ATPase V0 subunit a2TJ6, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2, ATP6V0A2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human ATP6V0A2.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:207

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 102% (by SDS-PAGE).

Specificity: ATP6V0A2 polyclonal antibody detects endogenous levels of ATP6V0A2 protein.

Molecular Weight: ~ 98 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -27°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9Y487

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only