ATP7B Polyclonal Antibody - BT-AP00748

ATP7B Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00748-20, BT-AP00748-50, BT-AP00748-100

Citations, Manuals and MSDS Available upon request.

Background: ATP7B (ATPase copper transporting beta) is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in ATP7B have been associated with Wilson disease (WD).

Research Areas: Signal Transduction; Metabolism

Target Protein: ATP7B

Applications: IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: ATP7B Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 157334

UniProt Accession: Human: P35670; Mouse: Q64446; Rat: Q64535

Synonyms: ATP7B; PWD; WC1; WND; Copper-transporting ATPase 2; Copper pump 2; Wilson disease-associated protein

GeneID: Human: 540; Mouse: 11979

Research Use Only