ATR (Phospho-Thr1989) Rabbit Polyclonal Antibody - BT-AP06215

ATR (Phospho-Thr1989) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06215-20, BT-AP06215-50, BT-AP06215-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs the PI3/PI4-kinase family| and is most closely related to ATM| a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3| a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1| checkpoint proteins RAD17| and RAD9| as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported| however| its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Research Areas: Cancer; Epigenetics and nuclear signaling

Target Protein: ATR

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: ATR

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q13535; Mouse: Q9JKK8

Synonyms: ATR;Thr1989; Serine/threonine-protein kinase ATR; EC 2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1

GeneID: Human: 545

Research Use Only