Product Description

AURKAIP1 Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-10976-60, E-AB-10976-120, E-AB-10976-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: AURKAIP1

Target Synonym: 28S ribosomal protein S38; AIP; AKIP; AURKA interacting protein; AURKA-interacting protein; AURKAIP 1; Aurkaip1; Aurora A kinase interacting protein; Aurora kinase A interacting protein 1; Aurora kinase A-interacting protein; FLJ20608; mitochondrial; MRP-S38

Research Areas: Cancer, Cell Biology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human

Application: WB, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9NWT8

Background: AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3, 000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Concentration: 0.2 mg/mL

Immunogen: Recombinant protein of human AURKAIP1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 22kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only