Product Description

AVEN Polyclonal Antibody

Sizes: 60μL, 120μL, 200μL

Catalogue Numbers: E-AB-15518-60, E-AB-15518-120, E-AB-15518-200

Citations, Manuals and MSDS Available upon request.

Abbreviation: AVEN

Target Synonym: 1700013A01Rik; 1700056A21Rik; Apoptosis caspase activation inhibitor; AVEN; AVEN; Cell death regulator Aven; mAven L; mAven S; MGC124011; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2

Research Areas: Cancer, Cell Biology

Conjugation: Unconjugated

Host: Rabbit

Species Reactivity: Human, Mouse

Application: WB, IHC, ELISA

Isotype: IgG

Clonality: Polyclonal

UNIProt ID: Q9NQS1

Background: AVEN, a cell death regulator, is an important signal inducer in acute leuke-mias. AVEN is a highly conserved peripheral membrane protein that protects the cell against the proteolytic activation of caspases as well as Apaf-1 mediated apoptosis by interfering with Apaf-1’s ability to self-associate. Bcl-2 and Bad also interact with AVEN to prevent apoptosis. AVEN is highly expressed in ovary, heart, thymus, spleen, testis and colon, but can also be detected in other tissues. Erythropoietin and methylprednisolone may play important roles in the expression of AVEN in cardiac tissue, especially after a traumatic brain injury. In young patients suffering from acute lymphoblastic leukemia (ALL), AVEN expression may be a useful tool in prognosis prediction.

Concentration: 0.4 mg/mL

Immunogen: Synthetic peptide of human AVEN

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Calculated MW: 39kDa

Storage: -20°C/One year. Avoid freeze / thaw cycles.

Shipping: Ice bag

Research Use Only