Product Description

AVP Receptor V2 (L111) Polyclonal Antibody

Catalogue Numbers: BS3210-50, BS3210-100

Sizes: 50µl, 100µl

Alternative Name: Vasopressin V2 receptor; V2R; AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor; AVPR2; ADHR; DIR; DIR3; V2R

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P30518

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IF

All Applications: WB: 1:500~1:1000
IF: 1:50~1:200

Background: The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney. Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP. The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system. The AVP Receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores. AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: AVP Receptor V2 (L111) polyclonal antibody detects endogenous levels of AVP Receptor V2 protein.

Bioworld Molecular Weight: ~ 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of AVP Receptor V2 (L111) polyclonal antibody at 1:500 dilution
Lane 1: 786-O whole cell lysate(40ug)
Lane 2: HEK293T whole cell lysate(40ug)
Lane 3: The kidney tissue lysate of Mouse(40ug)
Lane 4: The kidney tissue lysate of Rat(40ug)
Lane 5: PC12 whole cell lysate(40ug)

Immunogen: Synthetic peptide, corresponding to amino acids 80-130 of Human AVP Receptor V2.

Conjugate: Unconjugated

Modification: Unmodified