AVP Receptor V2 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA22263-50, RA22263-100
Citations, Manuals and MSDS Available upon request.
Background: arginine vasopressin receptor 2 (AVPR2) Homo sapiens This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: WB 1:500-2000, ELISA 1:10000-20000
Alternative Names: Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)
Applications: WB; ELISA
Species Cross-Reactivity: Human; Mouse
GeneID (Human): 554
Protein MW (KDa): 57
SWISS: P30518
Source: Rabbit
Research Use Only