AZ1 rabbit pAb - ES6440

AZ1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6440-50, ES6440-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms

Alternate Name: OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000, WB 1:500-2000

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Human Gene ID: 4946

Human SWISS Prot NO: P54368

Subcellular Location: nucleus, cytoplasm, cytosol,

Research Use Only