B7-H3/CD276 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-68332-60, E-AB-68332-120, E-AB-68332-200 Citations, Manuals and MSDS Available upon request. Abbreviation: B7-H3/CD276 Target Synonym: CD276; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2 Research Areas: Cancer, Immunology, Stem Cells Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human Application: WB, IHC Isotype: IgG Clonality: Polyclonal UNIProt ID: Q5ZPR3 Background: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Concentration: 1 mg/mL Immunogen: A synthetic peptide of human B7-H3/CD276 Buffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3. Purification Method: Affinity purification Dilution: WB 1:500-1:2000, IHC 1:50-1:200 Calculated MW: 33kDa/52kDa/57kDa Observed MW: 120kDa Storage: -20°C/One year. Avoid freeze / thaw cycles. Shipping: Ice bag Research Use Only