Product Description

BACE (D492) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1382-50, BS1382-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Autosomal dominant Alzheimer’s disease is caused by mutations in the gene encoding the β-amyloid protein precursor (APP). Amyloid β-peptide(Aβ), the major feature of amyloid plaques in Alzheimer’s patients, is the product of APP cleavage by β- and γ-secretases. BACE is the transmembrane protease which cleaves Aβ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE has a molecμlar mass of ~70 kDa, larger than predicted due to glycosylation, and is localized within Golgi and endosomes.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: IHC, IF

Alternate Names: Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, BACE, KIAA1149

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 480-520 of Human BACE.

Dilution: IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: BACE (D492) polyclonal antibody detects endogenous levels of BACE protein.

Molecular Weight: ~ 50 kDa

Pathway: Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P56817

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only