BACE Monoclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA10827-50, RA10827-100 Lead times: 1-2 weeks, if manufacturer has product in stock Manufacturer/Ship Location: China Background: beta-secretase 1 (BACE1) Homo sapiens This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015], Reactivity: Human, Rat, Bovine, Dog, Pig Host: Mouse Applications: WB Alternate Names: BACE1, BACE, KIAA1149, Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2 Clonality: Monoclonal Dilution: Western Blot: 1/1000 - 1/2000. Not yet tested in other applications. Storage: -20°C/1 year Condition: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol. Human Gene ID: 23621 Research Use Only