BAG5 Polyclonal Antibody-BS7862

BAG5 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7862-50, BS7862-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UL15

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB: 1:500~1:2000
IHC: 1:50~1:200

Background: Bag-5 (Bcl-2-associated athanogene 5), also known as Bag family molecular chaperone regulator 5, is a member of the Bag family of proteins and contains four Bag domains. Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis. Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BAG5 polyclonal antibody detects endogenous levels of BAG5 protein.

Bioworld Molecular Weight: ~ 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of extracts of various cell lines, using BAG5 antibody., Immunohistochemistry of paraffin-embedded human stomach using BAG5 antibody., Immunohistochemistry of paraffin-embedded rat brain using BAG5 antibody.

Alternative Name: BAG family molecular chaperone regulator 5;
BAG-5;
BAG5;
BAG5_HUMAN;
Bcl-2-associated athanogene 5;
BCL2 associated athanogene 5;
KIAA0873;

Immunogen: Recombinant full length Human BAG5.

Conjugate: Unconjugated

Modification: Unmodified