BAI1 Polyclonal Antibody
Sizes: 50μL, 100μL
Catalogue Numbers: RA22308-50, RA22308-100
Citations, Manuals and MSDS Available upon request.
Background: adhesion G protein-coupled receptor B1 (ADGRB1) Homo sapiens Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family,
Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instructions: -20°C/1 year
Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Alternative Names: Brain-specific angiogenesis inhibitor 1
Applications: WB; IHC-p; IF (paraffin section)
Species Cross-Reactivity: Human; Rat; Mouse
GeneID (Human): 575
Protein MW (KDa): 130-170
SWISS: O14514
Source: Rabbit
Research Use Only