BAI3 Polyclonal Antibody
Catalogue Numbers: BS60780-50, BS60780-100
Sizes: 50µl, 100µl
Alternative Name: Brain-specific angiogenesis inhibitor 3; BAI3; KIAA0550
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: O60242
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2, and BAI-3, are integral membrane proteins belonging to the G-protein coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI-3 is predominantly expressed in brain. Reduced expression may be observed in some glioblastoma cell lines suggesting that BAI-3 may function in the suppression of glioblastoma. Localization of BAI-3 in most neurons of the cerebral cortex is analogous with BAI-1 and BAI-2 expression in the adult brain, but varies in the developing brain. The activity of brain-specific angiogenesis inhibitor proteins has been inversely correlated with vascularization in some cancer tissues. BAI-3 activity may be significant in the early phases of ishemia-induced brain angiogenesis and in brain tumor progression. A better understanding of the anti-angiogenic activity of these BAIs may offer potential therapeutic benefits.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: BAI3 polyclonal antibody detects endogenous levels of BAI3 protein.
Bioworld Molecular Weight: ~ 172 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of BAI3 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: PC12 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human BAI3
Conjugate: Unconjugated
Modification: Unmodified