BAP1 (Phospho-Ser592) Rabbit Polyclonal Antibody - BT-AP06274

BAP1 (Phospho-Ser592) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP06274-20, BT-AP06274-50, BT-AP06274-100

Citations, Manuals and MSDS Available upon request.

Background: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition| the enzyme may be involved in regulation of transcription| regulation of cell cycle and growth| response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS)| which involves increased risk of cancers including malignant mesothelioma| uveal melanoma and cutaneous melanoma.

Research Areas: Cancer; Cell biology; Epigenetics and nuclear signaling

Target Protein: BAP1

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: BAP1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q92560; Mouse: Q99PU7; Rat: D3ZHS6

Synonyms: BAP1;Ser592; Ubiquitin carboxyl-terminal hydrolase BAP1; EC 3.4.19.12; BRCA1-associated protein 1; Cerebral protein 6

GeneID: Human: 8314; Mouse: 104416; Rat: 306257

Research Use Only