BAT3 Polyclonal Antibody-BS7715

BAT3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7715-50, BS7715-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P46379

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB 1:500 - 1:2000

Background: BAT3 (HLA-B associated transcript 3), also known as G3, scythe, BAG6 or D6S52E, is a proline-rich nuclear protein with an important role as an apoptotic regulator. BAT3 contains one ubiquitin-like domain at its N-terminus and two nuclear localization signals at its C-terminus. Specifically, BAT3 interacts with and stabilizes AIF (apoptosis inducing factor), thereby sensitizing the cell to apoptosis mediated by endoplasmic reticulum (ER) stress. Upon ricin treatment, BAT3 is cleaved by caspase-3 and its C-terminal fragment displays pro-apoptotic activities. The apoptotic activities executed include nuclear condensation, phosphatidlyserine externalization, cell rounding and shrinkage. Mice that are deficient in BAT3 exhibit pronounced defects in lung, brain and kidney development and in the regulation of proliferation and apoptosis. These defects ultimately result in perinatal or midgestational lethality.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BAT3 polyclonal antibody detects endogenous levels of BAT3 protein.

Bioworld Molecular Weight: ~ 160 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot analysis of extract of various cells, using BAG6 antibody.

Alternative Name: BAG 6;
BAG family molecular chaperone regulator 6;
BAG-6;
Bag6;
BAG6_HUMAN;
BAT 3;
BAT3;
BCL2-associated athanogene 6;
D17H6S52E;
D6S52E;
G3;
HLA B associated transcript 3;
HLA-B associated transcript 3;
HLA-B associated transcript-3;
HLA-B-associated transcript 3;
large proline rich protein BAG6;
Large proline rich protein BAT3;
Large proline-rich protein BAG6;
large proline-rich protein BAT3;
Protein G3;
Protein Scythe;
Scythe;
Scythe, homolog of Xenopus;

Immunogen: Recombinant full length Human BAT3.

Conjugate: Unconjugated

Modification: Unmodified