Product Description

Bax Mouse Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB9013-50, MB9013-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicμlar B cell lymphomas. Bcl-2 blocks cell death following a variety of stimμli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticμlum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Mouse

Applications: WB, ELISA, IHC, IF, ICC

Alternate Names: Apoptosis regμlator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX, BCL2L4

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human Bax: 31-130/192

Dilution: WB: 1:1000-1:1500
ELISA: 1:5000-1:10000
IHC: 1:100-1:500
IF: 1:200-1:500
ICC: 1:100

Purification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Bax Mouse monoclonal antibody detects endogenous levels of Bax protein.

Molecular Weight: ~ 21 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q07812

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only