BCAS3 rabbit pAb - ES6677

BCAS3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES6677-50, ES6677-100

Citations, Manuals and MSDS Available upon request.

Background: developmental stage:Fetal., disease:A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t (17; 20) (q23; q13) with BCAS4., similarity:Belongs to the WD repeat BCAS3 family., similarity:Contains 3 WD repeats., tissue specificity:Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.,

Alternate Name: BCAS3; Breast carcinoma-amplified sequence 3; GAOB1

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: Synthesized peptide derived from BCAS3 . at AA range: 660-740

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100kD

Human Gene ID: 54828

Human SWISS Prot NO: Q9H6U6

Subcellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Preautophagosomal structure. Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712).

Research Use Only