BCHE Polyclonal Antibody-BS90122

BCHE Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90122-50, BS90122-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P06276(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, ICC IHC

All Applications: WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: Present in most cells except erythrocytes, butyrylcholine esterase (BChE), also designated acylcholine acylhydrolase or pseudocholinesterase, has esterase activity as well as aryl acylamidase activity. It hydrolyzes acylcholine into choline and carboxylate. BChE is synthesized in the liver and is highly reactive with organophosphate esters. BChE can form a homotetramer composed of two dimers linked by a disulfide bond. Defects in the gene encoding BChE are associated with the disease hypocholinesterasemia. Inhibition of BChE effects the toxicity of organophosphates in the respiratory system suggesting that BChE may play a role in respiratory function. In addition, BChE may play an important pharmocological role by hydrolyzing toxic esters. This suggests an involvement of BChE in a treatment for intoxication with substances such as cocaine.

Purification and Purity: Protein affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: BCHE polyclonal antibody detects endogenous levels of BCHE protein.

Bioworld Molecular Weight: 68 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of BCHE on human blood plasma using anti-BCHE antibody at 1/1,000 dilution., ICC staining BCHE in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: BCHE, CHE1, Acylcholine acylhydrolase, BCHE, Butyrylcholine esterase, CHE1, CHE2, CHLE, Choline esterase II, Cholinesterase (serum) 2, Cholinesterase 1, Cholinesterase, E1, Pseudocholinesterase, Pseudocholinesterase E1,

Immunogen: Recombinant protein within Human BCHE aa 300-500.

Conjugate: Unconjugated

Modification: Unmodified