Bcl-2 Mouse mAb - EM1041

Bcl-2 Mouse mAb

Sizes: 50μL, 100μL

Catalogue Numbers: EM1041-50, EM1041-100

Citations, Manuals and MSDS Available upon request.

Background: BCL2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It regulates cell death by controlling the mitochondrial membrane permeability.

Alternate Name: B-Cell Leukemia/Lymphoma 2 ; B-Cell CLL/Lymphoma 2

Source: Mouse

Applications: WB, IHC, IF

Dilution: WB 1:1, 000-2, 000 IHC 1:200 IF 1:100-200

Reactivity: Human, Rat, Mouse

Immunogen: Synthetic Peptide

Storage and Stability: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality: Monoclonal

Isotype: IgG1

Concentration: 1mg/mL

Observed Band (KD): 26kDa

Human Gene ID: 596

Human SWISS Prot NO: P10415

Subcellular Location: Mitochondrion outer membrane, Nucleus membrane, Endoplasmic reticulum membrane

Research Use Only