Product Description

Bcl-6 (Acetyl Lys379) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA22346-50, RA22346-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with POU2AF1/OBF1., disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t (3;4) (q27;p11) with ARHH/TTF., disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t (3;14) (q27;q32); translocation t (3;22) (q27;q11) with immunoglobulin gene regions., function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis., induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan., PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway., similarity:Contains 1 BTB (POZ) domain., similarity:Contains 6 C2H2-type zinc fingers., subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9., tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: B-cell lymphoma 6 protein (BCL-6;B-cell lymphoma 5 protein;BCL-5;Protein LAZ-3;Zinc finger and BTB domain-containing protein 27;Zinc finger protein 51)

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 80

Protein Molecular Weight (kDa): 80

Storage: -20°C/1 year

Human Gene ID: 604

Human SwissProt Number: P41182

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only