Bcl-w rabbit pAb - ES1760

Bcl-w rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES1760-50, ES1760-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly (A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010],

Alternate Name: BCL2L2; BCLW; KIAA0271; Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human BCLW. AA range:131-180

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 25kD

Human Gene ID: 599

Human SWISS Prot NO: Q92843

Subcellular Location: Mitochondrion membrane; Peripheral membrane protein. Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Research Use Only