Product Description

BCLAF1 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61571-50, BS61571-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Apoptosis defines a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. Bcl-2 is one of many key regμlators of apoptosis which are essential for proper development, tissue homeostasis and protection against foreign pathogens. BCLAF1 (BCL2-associated transcription factor 1), also known as BTF, is a 920 amino acid protein that localizes to both the nucleus and the cytoplasm. Expressed throughout the body, BCLAF1 functions as a death-promoting factor that interacts with and represses the transcription of Bcl-2, thereby influencing the regμlation of apoptosis. Overexpression of BCLAF1 resμlts in the relocation of BCLAF1 to the nuclear envelope and the subsequent induction of apoptosis, an event that may occur as a resμlt of DNA damage. Four isoforms of BCLAF1 exist due to alternative splicing events.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Bcl-2-associated transcription factor 1, Btf

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 286-330 of Human BCLAF1

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Specificity: BCLAF1 polyclonal antibody detects endogenous levels of BCLAF1 protein.

Molecular Weight: ~ 150 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9NYF8

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only