Bcr Monoclonal Antibody-MB11934

Bcr Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB11934-50, MB11934-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: P11274

Host: Rabbit

Reactivity: Human, Rat

Applications: WB, IHC-P, IP,

All Applications: WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020]

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IgG

Bioworld Molecular Weight: Calculated MW: 143 kDa; Observed MW: 160 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Bcr in A549, HL-60, U2OS, C6 lysates using Bcr antibody., Immunohistochemistry analysis of paraffin-embedded Human Brain using Bcr antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Alternative Name: ALL; CML; PHL; BCR1; D22S11; D22S662

Immunogen: A synthetic peptide of human Bcr

Conjugate: Unconjugated

Modification: Unmodified