Bestrophin-1 rabbit pAb - ES20817

Bestrophin-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES20817-50, ES20817-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008],

Alternate Name: Bestrophin-1 (TU15B; Vitelliform macular dystrophy protein 2)

Source: Rabbit

Applications: WB; IHC; IF

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse

Immunogen: Synthetic Peptide of Bestrophin-1 AA range: 161-211

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 67kD

Human Gene ID: 7439

Human SWISS Prot NO: O76090

Subcellular Location: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane.

Research Use Only