Beta 2 Microglobulin Monoclonal Antibody-MB67043

Beta 2 Microglobulin Monoclonal Antibody

Catalogue Numbers: MB67043-50, MB67043-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P61769

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system . As an integral component of the MHC class I complex, β2-microglobulin plays a critically important role in immune system function . It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection . In addition, β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity ; its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of Beta 2 Microglobulin protein.

Extra Notes: Western blot analysis of Beta 2 Microglobulin expression in Jurkat (A), Hela (B) whole cell lysates.

Bioworld Molecular Weight: ~ 12 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Beta-2-microglobulin

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Beta 2 Microglobulin. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified