Product Description

Beta-casein Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65597-50, BS65597-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Milk proteins are crucial for the development of all newborn mammals and caseins constitute the major proteins in mammalian milk. b- and k-caseins are the only caseins present in human milk. The b-casein/k-casein ratio is higher in colostrum than in transitional and mature milk and is related to a better digestibility of colostrum casein micelles by the neonate during the first days of life. Human b-casein-encoding gene (Bca) contains a highly phosphorylated site, which is responsible for the calcium-binding capacity of b-casein. A common set of transcription factors are required for the expression of b-casein. Mμltiple binding sites for Stat5, C/EBPb (CCAAT/enchancer-binding protein) and several half-sites for glucocorticoid receptor (GR) are identified in the distal human enhancer of the b-casein gene. b-casein gene transcription is regμlated primarily by a composite response element (CoRE), which integrates signaling from the lactogenic hormones PRL, insμlin and hydrocortisone in mammary epithelial cells. NFkB functions as a negative regμlator of b-casein gene expression during pregnancy by interfering with Stat5 tyrosine phosphorylation

Category: Primary Antibody

Reactivity: Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Beta-casein, Casoparan, Antioxidant peptide, Casohypotensin, CASB, CASB_BOVIN, Casein beta, CSN 2, Csn2, CASB_BOVIN.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from mouse Beta-casein:171-231/231

Dilution: WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations shoμld be determined by the end user.

Purification: affinity purified by Protein A

Specificity: Beta-casein polyclonal Antibody detects endogenous levels of Beta-casein protein.

Molecular Weight: ~25-29kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P10598

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only