Product Description

Biglycan Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90136-50, BS90136-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P21810(Human) P28653(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC FC IP,

All Applications: WB:1:500-1:1000
IHC:1:50-1:200
FC:1:50-1:100

Background: Biglycan, a class I small leucine rich proteoglycan (SLRP) present in the extracellular matrix, influences bone cell differentiation and proliferation. Biglycan contains two chondroitin sulfate glucosaminoglycan (GAG) chains attached near its amino terminus, whereas a closely related SLRP, decorin, contains only one. Biglycan deficient specimens possess diminished capacity to produce bone cells precursors, a lessened response to TGFβ, reduced collagen synthesis, and increased apoptosis. Patients with rheumatoid arthritis express increased immunity to biglycan whereas osteoarthritis patients do not, suggesting that higher immunity to SLRPs may play a role in the pathogenesis of inflammatory rheumatic diseases.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Biglycan polyclonal antibody detects endogenous levels of Biglycan protein.

Bioworld Molecular Weight: 42 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Biglycan on mouse heart and human skin tissue lysates using anti-Biglycan antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-Biglycan antibody. Counter stained with hematoxylin.

Alternative Name: BGN, SLRR1A, BGN, Biglycan, Biglycan proteoglycan, Bone/cartilage proteoglycan I, Dermatan sulphate proteoglycan I, DSPG1, PG S1, PG-S1, PGI, PGS1, SEMDX, SLRR1A, Small leucine rich protein 1A,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified