BinCARD Polyclonal Antibody - BT-AP00902

BinCARD Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP00902-20, BT-AP00902-50, BT-AP00902-100

Citations, Manuals and MSDS Available upon request.

Background: BinCARD (Bcl10-interacting CARD protein) is a 228 amino acid protein that exists as two alternatively spiced isoforms. BinCARD localizes to nucleus and is expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart, liver, thymus and brain. Containing a CARD domain, BinCARD plays a role in inhibiting the effects of Bcl10-induced activation of NFκB possibly by inhibiting the phosphorylation of Bcl10 in a CARD-dependent manner. The BinCARD gene maps to chromosome 9q22.1. Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKAP.

Research Areas: Signal Transduction

Target Protein: C9orf89

Applications: IHC-p, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: BinCARD Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 25589

UniProt Accession: Human: Q96LW7; Mouse: Q9D1I2

Synonyms: C9orf89; Bcl10-interacting CARD protein; BinCARD

GeneID: Human: 84270; Mouse: 68480

Research Use Only