Product Description

Biotin Anti-Human CD127/IL-7RA Antibody [A019D5]

Sizes: 25μg, 100μg

Catalogue Numbers: E-AB-F1152B-25, E-AB-F1152B-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: CD127/IL-7RA

Target Synonym: Interleukin-7 receptor subunit alpha, IL-7RA, CDw127, CD127, IL-7Rα,

Conjugation: Biotin

Host: Mouse

Species Reactivity: Human

Application: FCM

Usage: Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Isotype: Mouse IgG1, κ

Clone No.: A019D5

UNIProt ID: P16871

Background: CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

Concentration: 0.5 mg/mL

Control Catalogue Number: E-AB-F09793B

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Gene ID: 3575

Storage: This product can be stored at 2-8°C for 12 months. Do not freeze.

Shipping: Ice bag

Research Use Only