Product Description

BLNK Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB10626-50, MB10626-100

Product: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Swiss-Prot: Q8WV28

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB,IP

All Applications: WB: 1/500-1/1000 IP: 1/20

Background: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification and Purity: Affinity Purified

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of BLNK in K562, C6, 3T3, HelaLysates using BLNK antibody.

Bioworld Molecular Weight: Calculated MW: 50 kDa; Observed MW: 70 kDa

Specificity: IgG

Alternative Name: BLNK; BASH; SLP65; B-cell linker protein; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; Cytoplasmic adapter protein; Src homology 2 domain-containing leukocyte protein of 65 kDa

Immunogen: A synthetic peptide of human BLNK

Conjugate: Unconjugated

Modification: Unmodified