Product Description

BLNK Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB67162-50, MB67162-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: B cell linker protein (BLNK), also known as SLP-65 or BASH, is an adaptor molecμle that plays key roles in B cell activation and B cell antigen receptor (BCR) engagement. BLNK acts at the interface between BCR-associated Syk and downstream signaling cascades. BLNK has mμltiple SH2 binding motifs (YXXP) at its amino terminus and an SH2 domain at its carboxy terminus. After BCR ligation, BLNK is phosphorylated by Syk at mμltiple YXXP motifs including Tyr72, Tyr84, Tyr96, and Tyr178 . These phosphorylated motifs provide docking sites for signaling molecμles, such as BTK, PLCγ, and Vav. These signaling molecμles bind to BLNK through their SH2 domains and together activate downstream signaling pathways. Through its SH2 domain, BLNK can also interact with tyrosine-phosphorylated targets, such as HPK1, thereby recruiting them to the BCR complex for signaling.

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB

Alternate Names: BASH, SLP65, B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BLNK. The exact sequence is proprietary.

Dilution: WB (1/500 - 1/4000)

Specificity: Recognizes endogenous levels of BLNK protein.

Molecular Weight: ~ 68 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8WV28

Product: Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Research Use Only