Product Description

BLNK (N91) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS2547-50, BS2547-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: B-cell linker protein (BLNK, also known as SLP65, BASH, and BCA) is a B cell adaptor that plays an important role in B cell development and in BCR-signal transduction. Since BLNK does not encode any intrinsic enzymatic activity, its function is to serve as a scaffold for assembling macromolecμlar complexes which includes enzymes (PLC gamma, Vav and Btk) and additional linker proteins (Grb2 and Nck) (1-3) . In addition, BLNK binds Btk and is required for activation of the transcription factor NF-κB. Tyrosine phosphorylation of BLNK by Syk provides specific docking sites for these SH2-containing effector proteins which in turn permits phosphorylation and/or activation of their respective signaling pathways.

Category: Primary Antibody

Reactivity: Human, Mouse

Host: Rabbit

Applications: IHC

Alternate Names: B-cell linker protein, BASH, BASH, Bca, Bca, BLNK, BLNK s, BLNK, Cytoplasmic adapter protein, Ly 57, Ly 57, Ly57, Lymphocyte antigen 57, Lymphocyte antigen 57, Lyw 57, Lyw57, Lyw57, MGC111051, SLP 65, SLP 65, SLP-65, SLP65,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 60-107 of Human BLNK.

Dilution: IHC: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: BLNK (N91) polyclonal antibody detects endogenous levels of BLNK protein.

Molecular Weight: ~ 68, 70 kDa

Pathway: B cell receptor signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8WV28

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only